invite friends ⋅ share email twitter ⋅ join discord whatsapp(2ck)
support the site ⋅ become a member ⋅ unscramble the egg
free120  nbme24  nbme23  nbme22  nbme21  nbme20  nbme19  nbme18  nbme17  nbme16  nbme15  nbme13 

NBME 20 Answers

nbme20/Block 3/Question#15 (31.8 difficulty score)
A 23-year-old woman, who was diagnosed with ...
Substance P🔍
tags:

Login to comment/vote.


 +4 
submitted by poisonivy(27),

Per UWorld; capsaicin found in chili peppers causes excessive activation of TRPV1 (transmembrane channel), which increases intracellular calcium that results in long-lasting dysfunction of nociceptive nerve fibers (defunctionalization). It also causes release and depletion of Substance P, causing at first burning and erythema but over time causes decreased pain sensation.




 +1 
submitted by hayayah(1000),
unscramble the site ⋅ become a member ($35/month)

nabcSuest P P(S) si an dnueipcepaedt spenetr ni het NSC and hte praplehrei ersvoun yemtss. A unmcoopd htougth ot eb lnvedivo ni teh spacniyt innmssstroai fo apni nad hrteo reevn uies.mspl

mambaforstep  also, apparently enkephalins attenuate substance p... so it would be dec her pain. +  



 +0 
submitted by poisonivy(27),

Per UWorld; capsaicin found in chili peppers causes excessive activation of TRPV1 (transmembrane channel), which increases intracellular calcium that results in long-lasting dysfunction of nociceptive nerve fibers (defunctionalization). It also causes release and depletion of Substance P, causing at first burning and erythema but over time causes decreased pain sensation.

chandlerbas  also topical Rx for post herpetic neuralgia +  



 +0 
submitted by step1soon(43),

Capsaicin induces the release of substance P, one of the principal chemo-mediators of pain impulses from the periphery to the central nervous system (CNS). After repeated application, capsaicin depletes the neuron of substance P and prevents its reaccumulation.