Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
hTis hsa ot od htiw tonrin c.nlpsigi eeemRrbm GGAT. Thsi aottunim idceudn an GA oslerc wrhee it aws sdopspue to b,e os semo of tath ntrino sutj eaebmc an .enox
I reiperdettn ncqe"eesu osrgudrnniu irtfs owt soxne fo gn"ee - to nmae hety smtu be ilnktga btoua t.nrosni There of teh nsaerw eiocsch ot'nd aveh ucmh to do hitw osirtn.n
ttha mya ton eb ari h,gitt tbu ehpsl nwraor wdo.n slAo nokignw oesm sa-smlBaehtai si edu ot tiasnrva ni raonbaml licsnpgi .phles (AF 2091 gp 4)3
oals emrbemer tath sihamleBaast- is due to tonpi otsuatnim in elipcs steis dna mrproeot scnuqeees 1(AF9 g)410p. fI oyu rtceae a naiuttom in a eislcp tsie uoy lilw uyrsle essm up the rrccoet ANRm eeddne ot keam a lnnucftaoi ig-nBlbo entrpi.o ahTt si who I sdraenwe eth isneot.qu
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$279$49sA debecsdri in teh nqosieut ste,m hsit itmutaon crusco tiwnih an nitnor (a eneg mnseetg which is rarsebnidtc DN]AA-[gNt;&R btu not anle)ttsd.ra NAR pilscnig n(syzem)e ragb ANR and lp“oo ;i”t an rnoint si ctu otu dna eth onsxe on riethe sedi fo teh noitrn era i,aenjddo elik hist:
r—e2xoen—o1inxonnt ;&=tg nox2xen1—eo
lTlp,yicay hits iglisncp ccrsou at eth vyer gseed of hte intorn tawh( I noteded itwh eth “—” .rtcr)aehac Btu in our acse, a unttomia hntiwi teh tonrin is sincgua NRA slingcpi enzeym ot eenizcorg a nwe :iste eht sceplri suct iwihtn the ntirno eansitd( of at the evyr eged, as ti )udlso.h o,S ew etg enhgtsiom that okslo keil s:thi
1oeo—2ntn—exrixn
’ahTts a oyatllt enrefidft AmRN eulle,omc nda 'sti ggoin ot akme ruo βn-giblo enrtoip olko dna( eabhev) ayfwull gnearts.
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