Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
This ahs to od wthi rtinno sicnip.gl embeRerm .GTAG sihT ttmuaion ddeiucn na AG ocsler eherw it asw sepsdoup ot ,eb os mose fo tath rnoitn tsju eecbma na n.eox
I enrirtetdpe "suenecqe inrdruosung firts wot xsoen of "ngee - to enam yeth mstu eb ngialkt oabut i.tronns Tehre fo het raeswn ocehcsi 'nodt heav umhc ot od ihwt nntis.ro
htta amy tno be ari ig,tth tub ehpls raronw wd.on Aols nkniwgo semo aasilmeha-tsB is ued to snvratia ni maoablnr iipcsnlg lep.sh F(A 9012 pg 34)
olsa emrberem that a-salematBhsi si edu to ontip mttosnaiu ni ilcpes istse nda mprorteo enceuseqs F(9A1 1)40gp. If yuo ectare a taonimut in a siepcl iest uyo lliw rylues sesm pu the crctoer ANmR nedede to ekam a otlnnciauf o-Bbignl iepornt. tTah si ohw I rnaseewd het tseu.oiqn
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$279$49sA drebedcis ni het noqtusie tsem, stih mttuaoin sruocc inhwti an nronti a( gene eemntgs hcwih si tasbenrdric A]D;NAR-&[Ntg ubt nto lstaa.n)erdt RAN cpslniig se(ney)mz rbga ANR dna “lopo i;t” na nonrti is utc tou nad the nsexo on erteih iesd of the otrinn aer e,jdnioda elik thi:s
nexn1nrn—oieoxo2—t =tg&; —oeoe12nxnx
lpliyTay,c htsi incsiplg rcucso at the veyr gesed of the onirnt (ahtw I deneotd hitw eth —“” a)rce.hcrta tuB in uor s,ace a animutto ithwni eht otirnn is naiuscg NAR cnpisigl zeyenm to izeenrocg a nwe s:iet hte prescil ctus wtiinh eth rntnoi e(dsanit of at hte yrve eged, sa ti u.sohdl) ,So we tge igohetsmn ttah oslok ilke sih:t
o—enxeno—12nirtx
tsa’Th a olylatt dfertefni RANm meuolc,le nad t'is ogngi to emak oru nolβg-ib eptrnio ookl dan( hbeav)e wulayfl rags.ent
$279$49