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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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As decisredb in eht eusinoqt mset, htsi ntamiout cscuro hnwiit an onrnti a( nege stgmnee hwchi is rnesibrtacd ;]NgANAD&R-t[ tbu tno ).aetlsrdnta NRA gpinslic )zmneyes( grba ARN and l“opo ;”ti an niornt is tcu tou and hte sxoen on eertih isde of hte inotnr rea d,ojidena klie hti:s

tnxn—r—xo1n2oeeion g=;t& noeo—xn2xe1

lliayTcp,y htsi cigslinp ucocrs ta teh very edsge fo teh rtnoni (thwa I oneedtd ihtw eth ”“— .aca)crreht utB in our ,csea a umtntoia twiinh het ronitn si iucsnag ANR lignspci ynmeze to eecrinogz a enw ei:ts the lescrip csut ihitnw eht rintno endia(ts fo at the revy e,ged sa ti )hdsuo.l ,So ew gte tmisenhog htta sokol like :hsit

——eo1erxin2nxont

Tshta’ a llytota nerdfetif ARNm omlue,elc and i'ts ogign ot kema ruo logiβ-nb tnopier look (and vaeb)he llaywuf egsnar.t

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drdanielr  I rmmebree atht in eth eARmp-rN, the scnlpigi teiss fo hte rnonit rhewe eht eimoscoslpe heactsta aer odrsdnurue yb U"G"-G-A- ekli ",augc" os hree eht omsolhooug AND ot htis trdnsa lduwo eb rcbnetidsar otin "...g........a.u"g...... dan isth lwudo ractee a '3 sliec seti too nsoo +7
vivarin  fi sthi si pdesopsu ot be m,pARreN- hwy aer erhet Ts' ni the eeuq?ncse I'm so efdcnsou yb tsih rfo omes arnoes +8
sars  Tish is teh neeg AN(,)D tno otneeehgruso AR.mN +
athenathefirst  ehT stgibeg leuc yeth dsia shit is B isltaa,shmae hwhci veen fi uoy nddi't ownk nyatihgn boaut xnsoe dna torsnni uoy olhsud vahe nonwk tath b ssaetaahmli olnvevis a intuamto in npcglisi ro ptoeromr iets taopmah( agep 4).4 I tog itsh usntqioe owrng oot (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype



 +5  upvote downvote
submitted by monoloco(155)
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sihT hsa to od wthi orinnt nii.gcpsl beeRrmem TGAG. sThi aimotunt ucenidd na GA ocsrel ewrhe it was deupposs to eb, os oesm fo atth rintno just eaebmc na .oxen

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 +4  upvote downvote
submitted by waterloo(126)
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I ieenrdteptr uneecq"se grusnidroun sfrit wto exnos fo eg"en - ot aemn eyth muts eb ktinalg btaou sr.inont hrTee of the nawser hiecosc on'dt ahve hcmu to od hiwt ions.trn

  • emnsises maouintt odulw aevh to be ni the nexo to asuec ncegah in omnai a.cdi
  • iopaonldnyyltea si at eth edn fo eht mRAN
  • thinoiibin of neorlcptiia is ADN

ttha yma ont be ria hg,tit utb hleps rrnowa wdo.n losA woknign seom B-hitsaeamsal is eud ot trsavain in marabonl psiginlc ehs.lp F(A 2910 gp )43

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 +1  upvote downvote
submitted by s1khwitit(1)
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lsoa eerrmemb thta Bsmaalhaites- is ued to onitp uansitmot ni ecspil siste adn orrotemp euqnseesc F9A1( 4).g1p0 If uoy etcrea a amotunit in a iepcsl tise ouy liwl srylue smse pu teh crcreot NRmA endede ot eamk a cunoftialn -onibBgl ieprot.n taTh si who I esnraedw teh tuoqis.ne

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