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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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sA berddceis ni hte usniqeot mtse, stih tumnatoi sccruo inwith na ionnrt a( gnee eetmsng wihch is cnaridsebrt N[tN]AR;ADg&- tbu otn d.elttar)ans ARN glinspic nesey)m(z agrb NRA dna “oopl ”t;i na rtinno si uct out dan the onxse no heiret eids fo teh rtonni rae adidj,noe klie si:th

otxn—2enoine—xro1n &g=;t e2e—x1nooxn

lyyi,pcTla hits nliispgc cocrus at eth vyre gdese of het rtnoin htw(a I deotend hitw teh ”“— t.)ehrcaarc But in oru cae,s a mntauoit hwitni the otnirn si aguinsc ARN ilcgpisn zyeemn ot gizcneeor a wne :itse the screipl sutc niithw the ionrnt naedt(si of ta het veyr dgee, sa ti d)lsou.h o,S ew egt nmhtogesi tath olkso klei s:ith

toox21—rneinxen—

aTh’ts a aoylttl eitedrfnf mNAR ulceoel,m nad 'sit ggion ot emka our go-ilnbβ toenipr loko and( havb)ee awfully tnsge.ar

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drdanielr  I rmbemeer htta ni hte Rme-pr,NA teh inlcpsig stsei fo hte innotr ewehr eth omseipseolc hcsttaae ear usdornedur by G-G-"A-U" ikle "guca", so eher eth sooomhugol ADN to shit nrtads uwlod be etiscrbrdan otni u...a........g"."...g... dna tshi uwldo erecta a 3' cslei esti oot oosn +7
vivarin  if tsih is odeuspps ot be e-,rpAmRN hyw rea erhte 'sT ni eth ?eueencqs I'm so efcsduno by htis ofr smeo naeors +8
sars  hTsi is het enge )(D,AN ont uthooesreneg AmN.R +
athenathefirst  The tgiesbg celu ythe idsa hsti is B ase,mlahista chwih neve if uoy ndtid' wokn yninhatg baotu nesxo adn nrtosni ouy sholud vhea nwonk tath b aaslsmhtiea eisvonlv a onmtiaut in incslpig ro orpmtoer siet hopmt(aa agpe 44.) I ogt htis oeqtisun ongwr oot (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype


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 +5  upvote downvote
submitted by monoloco(155)
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Tihs ahs to do with notnir .icsplnig mebremeR TAGG. Tihs atutomin nddeciu an GA lroesc hweer it was ussdeppo ot ,be so eosm of tath onritn tusj cbemea an x.eno

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 +4  upvote downvote
submitted by waterloo(126)
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I itrtnreedpe s"uneeceq dirgrnunsou istrf wto nxoes fo een"g - to naem heyt tusm be tliakng ubaot nosrnti. rheTe fo eht aenwrs hicscoe 'ondt ahev hmuc to od hwit s.ornitn

  • mniessse imunotta lwudo vhae ot eb ni teh xone ot cusae cgneah in nmiao .cdai
  • edpainlyoloatny si at teh dne of teh RAmN
  • inbntohiii of ecoratnlpii is NDA

ttha amy ton eb ari h,igtt tub lhsep roarwn wd.no solA kgiownn emso mlha-asatieBs si ude to aitavnrs ni marolban incsipgl lsh.ep F(A 2190 pg 43)

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 +1  upvote downvote
submitted by s1khwitit(1)
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osla ermrmbee taht ai-hstasmaBel is deu to ntipo utnsaitom in ielspc esits nad orpmreot eeqscsune (1A9F 0)4p1.g fI uyo ctreae a mittnoau in a espilc stei uyo lwil esryul smse up hte creotrc RNmA ndedee ot mkea a anlnuctifo lnbgoB-i e.pirnto aTht si hwo I renadsew het eqi.tsonu

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