Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
hsTi hsa to od hwit tniron ncsii.plg beermRme G.GTA ihTs namuitto didenuc na AG ceolrs ewerh it swa osupspde ot ,eb so omes fo htat rnnoti juts ebecma na n.xoe
I enetiprrdte cu"neseeq orununsirdg rstfi otw nexso fo "nege - to nmae hyte smut eb gktianl bouat s.otrnni rheTe fo teh rswnae csichoe d'not eahv hmcu ot od twih tosr.inn
thta aym tno be ari t,ghti tbu hlesp wrrnoa .ownd slAo kiwngno eosm hmsisaB-eatal si deu to vniasart in aoblnarm inpigslc el.sph F(A 9021 pg 4)3
soal remrebme that simatBaehsl-a si deu ot otinp nutasimto ni isepcl isste nda eorropmt eusseqenc FA(91 .gp401) If ouy eratec a utimoant ni a piecls tise you liwl uslery smes up teh certroc RmNA needed ot kema a cufinaonlt bBn-iolg neiropt. taTh is how I warednes het u.eiqnost
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$279$49As dredsbiec ni hte oinetqsu set,m tshi ontmuita uccsor nwhiti an ntrino (a ngee tengsem hhwic is ecartbsinrd AR;]tNDgN[-&A ubt ton t.aert)sdlan NRA nicipgsl enze)ys(m rbag ARN adn olo“p i;”t na irnont is uct uto adn hte eosnx on iehetr eisd of eht norint rea dinojdae, liek ish:t
o—en2rtnoixo1en—nx ;tg&= 2xno—eenxo1
,aiycTllpy shti gsiilnpc cuocsr ta the evyr eegsd fo het nntrio wt(ah I eoneddt hiwt eht —”“ ahatcr.re)c But ni ruo a,sce a nmtiatou wtiinh eht nrnoti is gicsanu NRA ilscping emnyez ot nereczgoi a wne s:iet the icerlps tscu hiiwtn the tionrn (ietsand fo ta teh ryev de,ge as ti )usdl.ho So, we teg hmesitngo ttah oloks ikle hsti:
nxno—onr2—xee1ti
atT’sh a tllayot tnfefeird ARNm ,cullemoe and 'tis giong ot mkae our bgβil-on ieopnrt oklo a(dn )heevba yflwalu a.tesrgn
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