Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.
The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype
siTh has to do wthi ntrion sinlc.gpi reeembRm GAG.T hTis oumntati dedcniu an AG scerlo rweeh ti swa upossped to ,eb so meso fo atht trinon utsj aeecbm na eox.n
I peridertetn eenu"esqc dgorsiunrun isrft owt xnoes fo ne"ge - to mnae tyeh sumt be gklnati otuba srtinn.o rThee fo the ranesw chcesoi 'odtn ehva hucm ot od whit snro.int
hatt aym not eb ria g,ihtt but sehpl raworn .wdon oslA gwninok some ealhBmstia-sa is ude to tivasanr in brlamoan csipnigl hpel.s (FA 1290 gp 43)
oals remmerbe thta slmthe-asiaaB si eud to ipont mtstnaoui in sepcil essit adn tpomorre ecusqnese F9A1( )g04p1. fI you ecarte a oittaunm in a ecplis iest you liwl uesrly mses pu the crterco AmRN denede ot eakm a aioltcfunn -nbgBoil tirnepo. aTht is who I wrsaneed teh .siqeuont
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$279$49As sdebecdri in eht eistqnou ,semt thsi otitnuma ucrcso inwith na tnoirn a( eeng tegsmen hcwih si acnirrsebtd A[]RtNNA&-D;g btu not .std)atlnera ARN glscniip e)szy(nem argb NAR and “polo ”ti; na ontnir is cut tou dna hte xesno on riethe ieds fo eth tornni ear nia,joded eilk isht:
ooxxno——trn1ei2nne ;=> 2e1nxoeno—x
piTclyl,ay stih gnispcli uocrsc at eth yrve esged fo hte tnirno w(aht I doeedtn ihwt eth ”“— t).chrreaca utB in rou ec,sa a mnuiotat inhiwt the tronin is nigusca RNA ncligspi mzeeyn ot ozegencir a nwe iet:s het pcslire ucts itinhw hte otnnri iesnt(ad of at the ervy ,eged as it usd.hlo) ,So we etg onmsihegt tath skloo klie t:his
—ne—o1x2eorinntx
’tashT a ttlolay tnfeidfer RNAm lecuem,lo nad s'ti igogn to aekm oru ogβ-bnli oeitpnr oolk d(na hv)aeeb wuyflla .erasgnt
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