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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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As sdebecdri in eht eistqnou ,semt thsi otitnuma ucrcso inwith na tnoirn a( eeng tegsmen hcwih si acnirrsebtd A[]RtNNA&-D;g btu not .std)atlnera ARN glscniip e)szy(nem argb NAR and “polo ”ti; na ontnir is cut tou dna hte xesno on riethe ieds fo eth tornni ear nia,joded eilk isht:

ooxxno——trn1ei2nne ;=> 2e1nxoeno—x

piTclyl,ay stih gnispcli uocrsc at eth yrve esged fo hte tnirno w(aht I doeedtn ihwt eth ”“— t).chrreaca utB in rou ec,sa a mnuiotat inhiwt the tronin is nigusca RNA ncligspi mzeeyn ot ozegencir a nwe iet:s het pcslire ucts itinhw hte otnnri iesnt(ad of at the ervy ,eged as it usd.hlo) ,So we etg onmsihegt tath skloo klie t:his

—ne—o1x2eorinntx

’tashT a ttlolay tnfeidfer RNAm lecuem,lo nad s'ti igogn to aekm oru ogβ-bnli oeitpnr oolk d(na hv)aeeb wuyflla .erasgnt

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drdanielr  I erermemb hatt in eht prNA,-Rem the lngicisp siets fo teh iontnr erwhe teh emplcoioess esaathct are rersudondu by -"G-UA-"G leki g"uc",a os reeh eth ooguhoslmo AND ot thsi nrsatd ouwdl eb inrrtsdcabe oint ....g.ga.....u.."....".. adn tish uoldw reecat a '3 lcsie ties too oons +7
vivarin  if thsi si ospupdse to eb pRmAN,re- hwy aer tereh Ts' in eht cqe?ensue 'Im os uncdefos yb tish orf oesm areosn +8
sars  shiT si the gnee )D,AN( otn gnoersueetho RANm. +
athenathefirst  ehT etgibsg cule hyet iads thsi si B ai,setmalash icwhh vnee if uoy ndid't nkow ygtniahn oabut snxeo adn rtinsno yuo ushold evah nwnok htta b heasilaatms ivelosnv a timonuat ni lsginipc or trpomroe stie hoaamp(t egpa .)44 I gto tihs quisento worgn oot (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype


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 +5  upvote downvote
submitted by monoloco(155)
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siTh has to do wthi ntrion sinlc.gpi reeembRm GAG.T hTis oumntati dedcniu an AG scerlo rweeh ti swa upossped to ,eb so meso fo atht trinon utsj aeecbm na eox.n

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 +4  upvote downvote
submitted by waterloo(126)
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I peridertetn eenu"esqc dgorsiunrun isrft owt xnoes fo ne"ge - to mnae tyeh sumt be gklnati otuba srtinn.o rThee fo the ranesw chcesoi 'odtn ehva hucm ot od whit snro.int

  • snseisem mtinaotu dwulo hvea to eb ni het neox ot aeucs nheagc in maino .diac
  • ndolyealpinyota is ta hte den of het mNAR
  • nhoiiiibtn of ilceainrotp is DAN

hatt aym not eb ria g,ihtt but sehpl raworn .wdon oslA gwninok some ealhBmstia-sa is ude to tivasanr in brlamoan csipnigl hpel.s (FA 1290 gp 43)

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 +1  upvote downvote
submitted by s1khwitit(1)
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oals remmerbe thta slmthe-asiaaB si eud to ipont mtstnaoui in sepcil essit adn tpomorre ecusqnese F9A1( )g04p1. fI you ecarte a oittaunm in a ecplis iest you liwl uesrly mses pu the crterco AmRN denede ot eakm a aioltcfunn -nbgBoil tirnepo. aTht is who I wrsaneed teh .siqeuont

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