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Retired NBME 20 Answers

nbme20/Block 1/Question#11 (reveal difficulty score)
The sequence surrounding the first two exons ...
Disruption of normal splicing by creation of a new 3′ splice site 🔍 / 📺 / 🌳 / 📖
tags: biochem dna repeat

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 +20  upvote downvote
submitted by drdoom(1206)
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As dcdberise ni teh sqniueot s,emt this oatmntui socucr tnwiih na nnotri (a nege esmetng chiwh is csitebrnrda NtAg-RNA;[&]D but ont ra)ttdsan.le ARN sclpgiin m(ye)sezn rbga ARN dan lo“po ti”; na oitnnr is uct uot dna eth oexsn no rhteei ieds fo teh otnnri rae ,ndeijdoa ikle :tshi

etnrie2o1nxnox—n—o &g;t= n1xe2eon—ox

l,yipyaTlc ihst ispngcli orccus at het rvye egdse fo eth ortinn taw(h I otdeedn wtih hte —”“ cehat)r.rca Btu in our ca,es a intmtoau hitwin hte tiornn si inacsug NAR igscnpil emnezy ot ezegorinc a wne tis:e hte lreiscp ctus nwitih eht nrntio tdisea(n fo ta het ervy eg,de sa ti l)hdsou. ,So ew get hsoigment taht soolk keil tshi:

ex2no—rnno—ti1xe

h’atTs a lloytat ntirfeedf mRAN uolce,elm dan s'ti noigg to maek rou nl-βgobi prtenio kloo (dan )evehba alluyfw ng.trsae

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drdanielr  I brmeeemr hatt ni het p-mrNeR,A teh cnpilisg sseit of the tnrion eherw eth oomseslpcie etthaacs ear nsrodeurdu yb UA---GG"" ilek g,uca"" so eerh het goosohloum NDA to isht artnds ouwdl be cdietbarnsr toni ....."...."..u..a....gg. adn tish dulow erecat a 3' lisec iste oto snoo +7
vivarin  if isth is psdepsou to eb AmN,rpeR- ywh aer hteer sT' in eht eseqec?nu 'mI os dfseunco by htis for semo anreos +8
sars  sThi is eht eegn )(A,ND ton hentroeseuog RN.Am +
athenathefirst  ehT btesggi eluc etyh dias tihs si B a,eihmaatlss whhic eevn if ouy n'tddi know hnitynga taobu exnso and tsinorn yuo doushl have knwon thta b ssataaehilm vneiolsv a miatunto ni pilniscg or pomretro seti at(amhop paeg )4.4 I gto tshi unqetsio rwgno too (: +1

Translocation may result in failure to transcribe RNA because of disruption of a regulatory element (eg, promoter) within a gene.

The affected gene will not be expressed or will be expressed in a dysregulated manner compared to the normal phenotype


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 +5  upvote downvote
submitted by monoloco(155)
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sThi sha ot do htiw iotnnr c.siilgpn bemeRrme AGT.G Tshi nituamot ddnueic na AG oelcrs wreeh it was puseopds to e,b os osem fo ahtt itrnon jsut mebeca an .exno

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 +4  upvote downvote
submitted by waterloo(126)
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I dtereteinrp qenusc"ee usgrndouinr rfist owt oxnes fo "egen - to maen yhte mstu eb altikng otabu osirtnn. rehTe of het areswn soeichc n'dto ehav hcmu ot od hwti onsir.nt

  • smissene tmuaotin owudl aveh ot eb in eht xeon ot sauce hcegna in oiamn cdi.a
  • tnaiayllnodpoey is ta the den fo eht NRmA
  • binniiotih fo eoticrnalpi si AND

thta amy otn eb ira hi,tgt ubt lhpse arrwno dw.no Aols ngkinow meso seBa-ihtalsam si eud ot rsnaiatv in nalmabor ipsgciln ph.esl F(A 1902 pg )43

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 +1  upvote downvote
submitted by s1khwitit(1)
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sloa meeermbr that hBaie-almatss is ued ot topin nstmoitau in spelci tesis nda eoprormt nquessece A9F(1 04.1g)p If uoy aterce a itntamou in a icepsl eits uyo lliw ruesyl emss pu eth tercroc RANm ddenee ot eakm a utincnalfo ilog-bnB pitoern. htaT is owh I nswderae hte is.ntqoue

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