NBME 20 Phosphoinositide hydrolysis (NBME Answers)

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Retired NBME Answer Explanations

Retired NBME 20 Answers

nbme20/Block 1/Question#25 (reveal difficulty score)
A 25-year-old primigravid woman at 42 weeks’ ...
Phosphoinositide hydrolysis 🔍 / 📺 / 🌳 / 📖
tags: biochem endo

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+13 upvote downvote
submitted by ∗hayayah(1212)

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Oxytocin uses IP3 signaling pathway.

GnRH, Oxytocin, ADH (V1-receptor), TRH, Histamine (H1-receptor), Angiotensin II, Gastrin.

FA mnemonic: "GOAT HAG"

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dickass I figured "if Oxytocin can cause milk secretion and enough uterine contractions to expel a full baby, it's probably activating smooth muscle contraction through Gq coupled second messengers" +9

randi signaling pathways in FA2019 p332 +3

realnorthomfs FA2020 p337 +

bfinard1 Can someone smarter than me explain how the IP3 pathway involves phosphoinositide hydrolysis? +

peachespeaches IP3=phosphoinositide +

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