share email twitter ⋅ join discord whatsapp(2ck)
free120  nbme24  nbme23  nbme22  nbme21  nbme20  nbme19  nbme18  nbme17  nbme16  nbme15  nbme13 

NBME 20 Answers

nbme20/Block 2/Question#22 (31.6 difficulty score)
A 44-year-old woman comes to the physician ...
Ubiquitin ligase🔍

Login to comment/vote.

submitted by hayayah(1057),
unscramble the site ⋅ remove ads ⋅ become a member ($39/month)

In rkiueaytoc ,elslc otw jomra y—awthpshtea upnetriaqtiobsueimo- athawyp adn ssoamylol lptoeody—imsetreais orpneti eiodgada.trn

eTh omjra awtpyah of ecvisetel rieoptn giadeardotn ni uareyctiko esllc uses iunbtqiiu sa a mrarke ttah getsatr csyootcli nad cnrelau pntisroe for drpai osrytilo.sep

heT eroth jaomr aywtpah of noiterp gaoetrdnaid ni uarcoitkey elcsl svoivlne eth tekupa of tiesnopr yb emyosloss dan iodsngiet yb etrospase.

missi199  Could I ask why it is not Lysosomal protease +7  
smc213  "Certain viruses have evolved to recruit the cellular E3 ligases to induce the degradation of cellular proteins that might have harmful effects on the viral life cycle. For instance, the protein E6 of Human papillomavirus (HPV) recruits the cellular E3 ubiquitin ligase E6-AP to induce ubiquitination and degradation of p53, thereby allowing viral replication." from: +3  
smc213  USMLE Kaplan: A majority of cellular proteins are degraded via the ubiquitin proteasome pathway, including many proteins that play a role in maintaining cellular homeostasis. These include proteins that regulate the cell cycle, apoptosis, etc. +3