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NBME 20 Answers

nbme20/Block 3/Question#15

A 23-year-old woman, who was diagnosed with Sjögren ...

Substance P

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submitted by hayayah(374),

Substance P (SP) is an undecapeptide present in the CNS and the peripheral nervous system. A compound thought to be involved in the synaptic transmission of pain and other nerve impulses.

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submitted by step1soon(2),

Capsaicin induces the release of substance P, one of the principal chemo-mediators of pain impulses from the periphery to the central nervous system (CNS). After repeated application, capsaicin depletes the neuron of substance P and prevents its reaccumulation.