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submitted by โˆ—shak360(23)
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Tihs eagp rmof 2F020A dan hrtoe souserrce hwso ttha nrteaic bla luesva in arcyngepn nsgrneiec rea adgcinitos ofr syriomT 12.

hTe eyas itgnh to bereermm is ttha in all oalmtsuoa iosrmseti PAPAP- si .aeedrdsec (nI mtiyosr 12 Do,nw 81 ,darsdEw and 31 u,ataP PPPA or egaercistasp-adconyn pasaml nropite is a)dce.sdeer

orF wDno nmdrosye i,icyflsepacl srrettef-tmisir atunodrlus cymmoonl swhos ncdearies nluhac ncalecrsynut adn islcypotaph naals oben.

lnyF,ila ni riytsmo 21 onDw de,ynomsr eth rkearsm era IH u,p sa ni

  • enrdcaies tCahbG-e eth( h ni mh)nau
  • dcaenires nhiiinb A

In ethor sroe,mitsi esthe lvaeus ear erceads.de

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shak360  In daiontdi ot A,-APPP APF or ieaoptnplra-toefh si soal rsededeac in lal of ehtes sesrdroid nda os is .ielostr nI f,atc it imthg eb srieae ot ermermbe atht abeCt-Gh nad( hiinIbn A) si just leeadtve ni onDw Syndorem adn tath ni reeyv other ieas,des verye vuael si cesardede as a ihst.ricue +

We said that AFP is decreased in autosomal trisomies, but it might be good to know that it is increased in Ataxia-telangiectasia (defect in the ATM gene leading to decreased IgA, spider angiomas, and ataxia) and within the realm of pregnancy, neural tube defects. In neural tube defects, neuropores fail to fuse in the 4th week leading to a persistent connection between the amniotic cavity and the spinal canal leading to an increased AFP in the amniotic fluid and maternal serum. This isn't the case in particular for spinal bifida occulta (the one with the tuft of hair) probably because of the lack of herniation. Remember that these diseases can also cause polyhydramnios (mainly anencephaly) due to the lack of a swallowing center in the brain.

+/- shak360(23)

AFP is also a tumor marker for Yolk sac tumors, mixed embryonal carcinomas (low yield), and hepatocellular carcinoma.

+/- shak360(23)


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