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submitted by โˆ—shak360(23)
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iThs peag ofmr 0F220A dna ehotr csseroeur sowh thta rcineta alb vlaeus ni enpcrnyga sngrineec aer isgaidcton orf Trysmoi 12.

eTh ayse tnhgi ot merbreme is atht ni all aoasluotm toisrsmei PAAP-P si esd.edacer n(I srotmyi 12 onD,w 81 awsdErd, nda 13 uat,aP PPAP ro eptnocsaegaracn-isyd lamspa orinpet is credseed)a.

orF wnoD enmsdyor lyciilac,fsep mrfitesrseitt-r urnatulsod lomcnyom wshso desneicra ahlcnu ycnutlrcesan dna phpicystalo anasl o.enb

,nFlyail ni yimrost 12 owDn my,dosrne het karrmse ear IH u,p sa ni

  • iacnseerd aehbCG-t hte( h ni )muahn
  • ciredneas inbiinh A

In orhte ,reiositms htese lsvaeu rea s.edacreed

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shak360  In tdanioid to PA-A,PP FPA or oipoprt-haeafenlt si alos saredeced in all fo sehte sdodsrrei nda so si relst.io nI tfa,c ti hgimt be aersie to mrmreebe atht bheGt-aC a(nd Iininhb )A si stju evdetlae in Dnow dyeormSn nda hatt ni yever orthe is,deaes reevy laevu si dersdeeac as a iiecr.stuh +

We said that AFP is decreased in autosomal trisomies, but it might be good to know that it is increased in Ataxia-telangiectasia (defect in the ATM gene leading to decreased IgA, spider angiomas, and ataxia) and within the realm of pregnancy, neural tube defects. In neural tube defects, neuropores fail to fuse in the 4th week leading to a persistent connection between the amniotic cavity and the spinal canal leading to an increased AFP in the amniotic fluid and maternal serum. This isn't the case in particular for spinal bifida occulta (the one with the tuft of hair) probably because of the lack of herniation. Remember that these diseases can also cause polyhydramnios (mainly anencephaly) due to the lack of a swallowing center in the brain.

+/- shak360(23)

AFP is also a tumor marker for Yolk sac tumors, mixed embryonal carcinomas (low yield), and hepatocellular carcinoma.

+/- shak360(23)

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