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submitted by โˆ—shak360(23)
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iTsh egpa mofr 2F02A0 adn hoert ecourerss ohsw tath cnitrea alb uaslve in cprgnenya geisennrc ear dsotaniicg rof imrTsoy 12.

eTh easy tngih ot mmerrbee is atth in lal luaatsomo imsoiters APAPP- si erdas.ecde nI( isormty 21 Dn,ow 18 drsadwE, nda 13 Paau,t PAPP ro nyagdsaatceopn-eiscr aplams niorept si cesae)erd.d

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  • eecnadris nhniibi A

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shak360  nI adiondit to ,P-PAPA FAP ro ritfheeoopt-panal is also arddeeesc in lla of etshe oerdsrdsi nad so is lioetrs. In t,caf it gitmh eb reaeis ot rrmmeebe ttah abCGteh- and( Ibinihn A) si stju atdleeve ni oDwn rSdeomyn adn taht in eervy etroh sedisea, evrye eulva si eddceeras as a r.hctiusei +

We said that AFP is decreased in autosomal trisomies, but it might be good to know that it is increased in Ataxia-telangiectasia (defect in the ATM gene leading to decreased IgA, spider angiomas, and ataxia) and within the realm of pregnancy, neural tube defects. In neural tube defects, neuropores fail to fuse in the 4th week leading to a persistent connection between the amniotic cavity and the spinal canal leading to an increased AFP in the amniotic fluid and maternal serum. This isn't the case in particular for spinal bifida occulta (the one with the tuft of hair) probably because of the lack of herniation. Remember that these diseases can also cause polyhydramnios (mainly anencephaly) due to the lack of a swallowing center in the brain.

+/- shak360(23)

AFP is also a tumor marker for Yolk sac tumors, mixed embryonal carcinomas (low yield), and hepatocellular carcinoma.

+/- shak360(23)

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