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submitted by โˆ—shak360(23)
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This paeg rmof F002A2 nda theor rosescreu owhs hatt atecrni abl savleu ni cnryeganp cgseinern ear niosadcigt rfo yomsTir 2.1

eTh syae igthn ot rmrbemee si htta ni lla osaatlumo smiorstei PPAA-P is edd.srecae (nI oyitmsr 21 wnoD, 81 sdd,rwEa nda 31 aPu,at APPP ro r-nsedpyienotcagasca lspaam entorpi si da)ercde.se

rFo noDw oemrsnyd ,syaicleiflcp irsrmetfiett-rs dsoltnauur molcomny shsow aiensrcde ulnhca lsyceurtancn dna aphspoclyti nslaa n.oeb

yl,lFnai in motisry 21 wnoD srnedmy,o hte mrksaer are HI up, sa ni

  • dneracsie -bhteCaG (het h in an)uhm
  • iecnesadr ibihinn A

In etorh oimtesris, etseh uavsle rae eecs.aderd

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shak360  In tiidonda to -APPAP, FAP ro ahlpoiropae-nfett is aslo acedersed ni lal fo heste eidrssord and so is erlo.ist In f,cat ti gmith eb isaree ot ebeemmrr atht G-eCbhat (nad bnInihi A) is jtsu davleeet ni Dwno oSedrnmy adn atth in eyerv ehrot saedei,s eyver uvael si eaceddsre sa a eihtrucsi. +

We said that AFP is decreased in autosomal trisomies, but it might be good to know that it is increased in Ataxia-telangiectasia (defect in the ATM gene leading to decreased IgA, spider angiomas, and ataxia) and within the realm of pregnancy, neural tube defects. In neural tube defects, neuropores fail to fuse in the 4th week leading to a persistent connection between the amniotic cavity and the spinal canal leading to an increased AFP in the amniotic fluid and maternal serum. This isn't the case in particular for spinal bifida occulta (the one with the tuft of hair) probably because of the lack of herniation. Remember that these diseases can also cause polyhydramnios (mainly anencephaly) due to the lack of a swallowing center in the brain.

+/- shak360(23)

AFP is also a tumor marker for Yolk sac tumors, mixed embryonal carcinomas (low yield), and hepatocellular carcinoma.

+/- shak360(23)

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