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submitted by โˆ—shak360(23)
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ishT eapg mfro 02F02A and ehrto eurrosesc hsow htta ecitrna bal auelsv ni yrnngcape isnercnge aer gdniisaotc ofr ysmoirT 1.2

The yaes nhgit ot mmerreeb si htat ni lal omlutasoa risitsoem PA-PPA si reddeasec. nI( tsirmyo 12 no,Dw 81 Ewsa,ddr adn 13 Pata,u APPP or tdaoarncpinyscee-ags malaps trieonp si .ea)ecsdder

For wnoD srdenmoy y,lpacfclisie i-ertfrsrmteits lduounarts mcylomno shsow eiecnasdr nuchal lrutncseancy and hptcaysiopl naals e.bon

iFnllay, ni ioymtsr 21 owDn eysrnmd,o eht akesrmr rae HI p,u sa in

  • crieesnda eC-abhtG (eht h in )uhnma
  • srecadien ihbnnii A

nI hotre im,orteiss eseht aeslvu era d.seeraced

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shak360  In todanidi ot AP-,PAP PAF or nrtelahiaofepp-ot si also dreedseca ni all of ehtes doersdsri adn so is rlsto.ie In ac,ft ti hitmg be eesair to ermmeerb ttah aeCthb-G (nad niIihbn A) si tsuj vtedalee in oDwn oreydnmS dan htat in revey ohrte sdesaie, ervey eavlu is rdeadeesc as a ecurh.tisi +

We said that AFP is decreased in autosomal trisomies, but it might be good to know that it is increased in Ataxia-telangiectasia (defect in the ATM gene leading to decreased IgA, spider angiomas, and ataxia) and within the realm of pregnancy, neural tube defects. In neural tube defects, neuropores fail to fuse in the 4th week leading to a persistent connection between the amniotic cavity and the spinal canal leading to an increased AFP in the amniotic fluid and maternal serum. This isn't the case in particular for spinal bifida occulta (the one with the tuft of hair) probably because of the lack of herniation. Remember that these diseases can also cause polyhydramnios (mainly anencephaly) due to the lack of a swallowing center in the brain.

+/- shak360(23)

AFP is also a tumor marker for Yolk sac tumors, mixed embryonal carcinomas (low yield), and hepatocellular carcinoma.

+/- shak360(23)

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