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Retired NBME Step 2 CK Form 6 Answers

step2ck_form6/Block 1/Question#26 (reveal difficulty score)
A 32-year-old woman comes to the physician ...
Polycystic ovarian syndrome ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: repro endocrine pcos infertility

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submitted by โˆ—carolebaskin(109)
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This is tricky because of the normal hormone levels

Usually PCOS has LH:FSH > 3:1

But, both can still be within the reference ranges!

Normal for females

  • FSH: 4-30 premeno, 10-90 midcycle, 40-250 postmeno
  • LH: 5-30 follicular, 75-150 midcycle, 30-200 postmeno

Also, testosterone often, but not always, elevated

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jlbae  Ooo that's dirty, dirty trick by our friends at the NBME. +3



 +1  upvote downvote
submitted by โˆ—sugaplum(487)
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Irregular periods, acne, and infertility line up with PCOS. Even though you don't palpate any masses on exam. The ovaries aren't necessarily palpably larger. I think of this like normal ovulation cysts that did not rupture properly, because they didn't get the correct signal (LH Surge)

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submitted by โˆ—kingfriday(45)
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This one got me :[ i was looking for the LH>FSH and the ovarian masses - but other than that i agree this pretty much matches up.

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submitted by โˆ—step_prep7(71)
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  • One of the most common causes of female infertility, especially in overweight women
  • Diagnosis requires 2 out of 3 of the following criteria: (1) Clinical and/or biochemical hyperandrogenism (2) Oligomenorrhea (3) Polycystic ovaries on pelvic ultrasound /// Our patient has clinical hyperandrogenism (acne vulgaris) and oligomenorrhea (irregular menses)
  • Key idea: Although often associated with insulin resistance and ultimately associated with development of Type 2 diabetes, insulin resistance is not formally included in diagnostic criteria
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