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nephroguy
All of this is correct except its intravascular hemolysis, not extravascular. Also look for hemosiderinuria, hemoglobinuria and schistocytes on blood smear
+3
dermgirl
Is not intravascular hemolysis, it is extrinsic hemolysis, specifically macroangiopathic hemolytic anemia. FA 2020 page 423.
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vishnu_c_singh
This is actually BOTH intravascular hemolysis & extrinsic hemolysis.
Extrinsic = hemolysis that isn't caused by an internal defect of the RBCs, like an enzyme/membrane defect (in other words, it's hemolysis due to an external factor like a mechanical valve).
Intravascular = hemolysis that occurs within the blood vessels (RBCs get damaged as they pass through the valve). This is in contrast to extravascular hemolysis which describes hemolysis that occurs outside of the blood vessels (e.g. inside the spleen)
+7
sexymexican888
This is so dumb... but helpful I just realized
-intrinsic hemolysis (something intrinsically wrong w/RBC i.e G6PD, PNH, sickle cell anemia, hereditary spherocytosis ) VS extrinsic hemolysis (something on the outside of RBC i.e. autoimmune hemolytic anemia, MAHA,mechanical destruction [aortic stenosis, infection) is NOT the same as
-intravascular (in blood vessels i.e. complement) VS extravascular hemolysis (in the spleen) so prosthetic valve hemolysis is INTRAVASCULAR EXTRINSIC hemolysis.
Hope this helps understand that better, theyre mostly classified by intrinsic/extrinsic (whats wrong with the RBC) vs intravascular/extravascular (where does it happen)
+4
dlakaswnd
playing offline nbme without a reference chart, thought it was like mediocre direct bilirubinemia ffff
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submitted by โdivya(75)
FA 2019 Pg 415
Prosthetic heart valves and aortic stenosis may cause hemolytic anemia secondary to mechanical destruction of RBCs.