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dulxy071
Wouldn't Granulation tissue be the (more correct) answer since the initial collagen laid down for wound healing is Type III collagen which is consistent of granulation tissue? Collagen is a vast for so many types of itself as we know
+4
kpjk
@dulxy071 she had a surgery 3 months ago
healing was fine even uptill 6 weeks ago
so the abnormality occurred during remodeling- when type 3 is replaced by type 1 collagen, so the answer wouldnt be granulation tissue
+6
pontiacfever
Keloid has both 1 and 3 types of Collagen increased production. Whereas, granulation tissue consists of type 3 collagen only.
which is why collagen synthesis as answer would be more specific
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whoissaad
Exactly my reasoning for not choosing collagen "synthesis"
+3
rockodude
dont overthink people, whether its an underproduction or overproduction of collagen, overproduction is still abnormal collagen synthesis. its abnormal to make an excessive amount of collagen 3 leading to a keloid
+6
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johnthurtjr
I think it may actually be a keloid, not a hypertrophic scar, as it expands beyond the borders of the original incision.
+6
thepacksurvives
I believe this is a keloid; a hypertrophic scar does not extend past the borders of it's original incision, while a keloid does. regardless, the answer to this question is the same :)
+1
breis
First AID pg 219
Scar formation: Hypertrophic vs. Keloid
+1
charcot_bouchard
They give granulation tissue is a option which is type 3 collagen. so if it was hypertrophic scar it would be ap problem since its only excessive growth of Type 3. while keloid is excessive growth of both 1 and 3
+6
bharatpillai
I literally ruled put collagen synthesis defect since this is not a collagen synthesis defect at all ( EDS, Scurvy) :/
hate these kind of questions
+1
kcyanide101
Base off pathoma, this is hypertrophic scaring, as it extends beyond its borders. It will be type 1 collagen. Keloid will be much more excessive and it is a type 3 collagen
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submitted by โchampagnesupernova3(93)
This is a keloid. In normal wound healing type 3 collagen is first synthesized and then degraded by Matrix metalloproteinase (a collagenase which uses Zinc as a cofactor) and replaced by Type 1. In a Keloid an excessive amount of disorganized Type 3 collagen persists. Therefore the defect is in Collagen synthesis (Type 1 synthesis)