NBME PCP (phencyclidine) (NBME Answers)

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submitted by benwhite_dotcom(465),

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PPC si a icydoeet-tnpihasv adn ciisodvaesti etacthneis atth lryglaeen atcs as a wondre tbu nca osla escau rlecbdniei sroasngige uelpodc whit naip ntyiesvstinii (eth nepusarm ).gurd Vtlarcei tmsgusyan si a onlyocmm innoemetd apclisyh eaxm iidfnng.

azibird FA specifically mentions hypertension and tachycardia, so I ruled it out immediately. But you're right, it's a hallucinogen, I thought it was a stimulant. +1

azibird "PCP (10mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norpinephrine in the hypothalamus and the brainstem regions." https://www.sciencedirect.com/science/article/abs/pii/0006899384901847 "Over 50% of adult patients present with the classic toxidrome of PCP intoxication: violent behavior, nystagmus, tachycardia, hypertension, anesthesia, and analgesia." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859735/ +

schep I spent so much time on this question. I also ruled out cocaine, methamphetamine and PCP because (I thought) his vitals didn't match. Then I was forced to convince myself that someone on oxy or a benzo would suddenly get violent... +