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free120/Block 2/Question#39 (8.5 difficulty score)
A 3-month-old boy is brought to the emergency ...
Decreased activity in the enzyme that reduces Fe3+ to Fe2+๐Ÿ”,๐Ÿ“บ

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submitted by aejinkim(7),

the hypoxia and the "blood sample appears brown" should point you towards methemoglobinemia.

if you want a fun video from "9-1-1" that actually explains a lot of it:

xmen  very nice videos +++ +1  

submitted by madden875(19),

From wikipedia:

"Spontaneously formed methemoglobin is normally reduced (regenerating normal hemoglobin) by protective enzyme systems, e.g., NADH methemoglobin reductase (cytochrome-b5 reductase), NADPH methemoglobin reductase, and the ascorbic acid and glutathione enzyme systems. Disruptions with these enzyme systems lead to methemoglobinemia."

submitted by mariame(8),,is%20unable%20to%20carry%20oxygen.

I was wondering why a baby could get methemoglobinemia. Some answers in the link.

submitted by hemoglobin_(1),

The congenital type is due to a deficiency of the enzyme NADH-cytochrome b5 reductase, which impairs the ability of hemoglobin to bind oxygen, leading to poor oxygenation of body tissues. Cyanosis and hypoxia result. Source: