Bisphosphonates work by decreasing osteoclast activity (thereby reducing bone resorption). โIncreased receptor activation of NFkB ligand (RANKL) productionโ is the opposite of how estrogen therapy works (RANKL is found on osteoblasts, and its activation triggers osteoclasts and stimulates bone resorption).
submitted by โbwdc(697)
Bisphosphonates work by decreasing osteoclast activity (thereby reducing bone resorption). โIncreased receptor activation of NFkB ligand (RANKL) productionโ is the opposite of how estrogen therapy works (RANKL is found on osteoblasts, and its activation triggers osteoclasts and stimulates bone resorption).