need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

NBME Free 120 Answers

free120/Block 1/Question#24 (reveal difficulty score)
A 33-year-old woman comes to the physician ...
Inactivation of cellular p53 ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–

 Login (or register) to see more

 +3  upvote downvote
submitted by โˆ—bwdc(697)
get full access to all contentpick a username

p53 protein is the quintessential tumor suppressor (it activates apoptosis). HPV carcinogenesis is caused by insertion of the virus into host DNA that produces a protein which binds to an essential p53 substrate, functionally inactivating p53 and preventing its apoptotic cascade. Transactivation/TAX is how HIV and HTLV cause cancer. c-myc translocation causes Burkitt lymphoma.

get full access to all contentpick a username
claptain  Just to add to this, HPV can also inactivate Rb via E7 viral protein. +3
mamorumyheart  E6: p53 E7: RB (from FA: 6 before 7, p before R) +3

Must-See Comments from free120

sugaplum on It is a polymorphism
bwdc on Elaboration of proteases and urease with ...
bwdc on Hypercoagulability from advanced malignancy
bwdc on Ribosomal assembly
bwdc on Aspiration
bwdc on Amygdala
imnotarobotbut on von Willebrand disease
bwdc on Trinucleotide repeat expansion
bwdc on Mediation of cell entry via a fusion protein
bwdc on Metabolism
bwdc on Basement membrane
melchior on Aspiration
hungrybox on Immune complex deposition in tissues
aejinkim on Decreased activity in the enzyme that ...

search for anything NEW!