need help with your account or subscription? click here to email us (or see the contact page)
join telegramNEW! discord
jump to exam page:
search for anything ⋅ score predictor (โ€œpredict me!โ€)

NBME Free 120 Answers

free120/Block 1/Question#29 (reveal difficulty score)
A 63-year-old homeless man is brought to the ...
C5a ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags:

 Login (or register) to see more


 +7  upvote downvote
submitted by โˆ—bwdc(697)
get full access to all contentpick a username

The arrow is pointing to a neutrophil (multilobed nucleus): main fighter of the immune system in acute inflammation and bacterial infection (such as aspiration pneumonia). C5a is a chemotactic factor for PMNs.

get full access to all contentpick a username
ibestalkinyo  Other chemotactic factors include IL-8 and LTB4 +6
j123  Note: C5a is a chemotactic factor for many immune cells in addition to neutrophils. Also, C3a is a chemotactic factor for just eosinophils and basophils (not neutrophils) +2
cheesetouch  Q. What's so sexy about C5a? A. It's like Chanel No. 5 for neutrophils: they smell it and come running. +11
igurl11  I guess I kind of overthought this and went back and forth between C5a (initial choice right off the bat) and Histamine (until I saw this... aaaand went into internal battle mode). Since it asked what cause the Neutrophil to be at that location, I thought margination and rolling would be the 1st reason that neutrophils move from center to the periphery via Histamine (VD -> center to margin) and then it would start to slow down via P- (WP bodies bc of Histamine) and E- (IL-1 and TNF)) selectin speed bumps. I did wonder if they wanted us to go with the adhesion portion which would be the C5a, LTB4 etc but was there anything that specifically pointed towards Adhesion vs Margination/rolling? I need to stop overthinking things xD +



 +1  upvote downvote
submitted by โˆ—an_improved_me(91)
get full access to all contentpick a username

So mad.. these don't even look like neutrophils! They all have what look like are 2 lobes.

I couldn't make heads or tails of what they were. I ended up thinking they were eosinophils (bilobed), even if they weren't exactly fileld with granules lol.

So much pain.

get full access to all contentpick a username
jbrito718  SAME! +1
an1  Even if the image was lame (which it was), he has an acute injury of some sorts. That helped tip me off for neutrophils (Pathoma: Fluid phase --> neutrophils --> macrophages) +



Must-See Comments from free120

sugaplum on It is a polymorphism
bwdc on Elaboration of proteases and urease with ...
bwdc on Hypercoagulability from advanced malignancy
bwdc on Ribosomal assembly
bwdc on Aspiration
bwdc on Amygdala
imnotarobotbut on von Willebrand disease
bwdc on Trinucleotide repeat expansion
bwdc on Mediation of cell entry via a fusion protein
bwdc on Metabolism
bwdc on Basement membrane
melchior on Aspiration
hungrybox on Immune complex deposition in tissues
aejinkim on Decreased activity in the enzyme that ...

search for anything NEW!