NBME C5a (NBME Answers)

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free120/Block 1/Question#29 (reveal difficulty score)
A 63-year-old homeless man is brought to the ...
C5a 🔍 / 📺 / 🌳
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+7
submitted by ∗benwhite_dotcom(653),

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ehT oarwr is tignnpoi to a lptohruine oulmibdle(t u)c:lnsue inma girthef fo eht umimen sytmse in utace oaamlnimnfit and calirbate cfiietonn (hscu as arpsiinota a.une)inomp Ca5 si a ecctmiatohc atfroc rof .PNsM

ibestalkinyo Other chemotactic factors include IL-8 and LTB4 +6

j123 Note: C5a is a chemotactic factor for many immune cells in addition to neutrophils. Also, C3a is a chemotactic factor for just eosinophils and basophils (not neutrophils) +2

cheesetouch Q. What's so sexy about C5a? A. It's like Chanel No. 5 for neutrophils: they smell it and come running. +7

igurl11 I guess I kind of overthought this and went back and forth between C5a (initial choice right off the bat) and Histamine (until I saw this... aaaand went into internal battle mode). Since it asked what cause the Neutrophil to be at that location, I thought margination and rolling would be the 1st reason that neutrophils move from center to the periphery via Histamine (VD -> center to margin) and then it would start to slow down via P- (WP bodies bc of Histamine) and E- (IL-1 and TNF)) selectin speed bumps. I did wonder if they wanted us to go with the adhesion portion which would be the C5a, LTB4 etc but was there anything that specifically pointed towards Adhesion vs Margination/rolling? I need to stop overthinking things xD +

+1
submitted by ∗an_improved_me(81),

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So .dm.a heset 'nodt neev loko ikle t!lunsrieoph yhTe lal ehav hawt olok like era 2 be.los

I untlcod' amek dsahe or litsa of htwa eyht .were I deedn pu tnkiinhg hyet ewer sinihploseo i,()oldbeb enev if tyhe r'ntewe laectyx dlilfe hwit uslgnare .oll

So cmuh np.ai

jbrito718 SAME! +1

an1 Even if the image was lame (which it was), he has an acute injury of some sorts. That helped tip me off for neutrophils (Pathoma: Fluid phase --> neutrophils --> macrophages) +