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free120/Block 0/Question#10 (reveal difficulty score)
A 22-year-old woman comes to the office ...
CD28 on T lymphocytes ⟶ CD80 on epidermal Langerhans cells πŸ” / πŸ“Ί / 🌳

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submitted by fullmetalapathist(7),
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DC80 si salo kwnno as 7.B usenoitQ si iasnkg if uyo know tath D2C8 llecT-s() ittacsnre hwit B7 (A)CP as a ly-mooacutsitr sgailn ot tateiavc teh

sokoL ilek eth ipcteru si darnitsnomegt otatcnc steiamitdr (ude to rhe retcne use of nwe hria )eyd ihwhc si a tyep IV SRH

I uslauyl mebmerre htat B7- si on hte Blcel- a(n PC)A

melchior  Reminder: CTLA-4 on T-cells also binds to B-7, and the effect is opposite that of CD28 (inhibits T cell activation) FA 2020 pg 222 +1  
mmizell  CD40L on T lymphocytes-> to CD40 on Langerhans cells is true association but doesn't answer the question because its co-stimulation induces B cell proliferation, not T cell proliferation. +3  

submitted by βˆ—aaftabsethi1(8),
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anC aeonyn tlle ohw a aihr dey fdtfeeca her mfreaor ?

vetafig692  lmao good question! +1  
chaosawaits  if you're asking that question, you're not ready to see what the pubic region looks like now +  

submitted by βˆ—an1(72),

History and image are a type 4 HSR. This is T cell induced. Cd40L --> Cd40 is T cell --> B cell CD28 (on T cell) --> binds to APC's (including Langerhans cells); CD80/ 86/ B7

Options with ICAM, I immediately crossed out because they're associated with margination and rolling, etc. CD45 isn't mentioned in regards to T cells (or anywhere I might add). Leaving us with the 2 options I mentioned above ^

submitted by βˆ—handsome(1),

FA 2020 pg 103 there's a diagram where you can see binding of B7 protein (CD80/86) ---CD28 as part of T cell activation.

Note: Langerhans cells (LCs) are a specialized subset of dendritic cells (DCs) that populate the epidermal layer of the skin.

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