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NBME Free 120 Answers

free120/Block 2/Question#35 (reveal difficulty score)
A 65-years-old woman with asthma is brought ...
Leukotrienes ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–

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submitted by โˆ—aakb(41)

I believe this is aspirin intolerant asthma. Aspirin inhibits cycloxygenase. This leads to more shunting of the arachidonic acid to the leukotriene pathway (excessively), which leads to a bronchospasm.

Aspirin-induced bronchospasms can occur in aspirin intolerant asthma occurs more in adults. Additionally, she experienced this previously with ibuprofen (another NSAID that inhibits cox).

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submitted by โˆ—moxomonkey(20)

In an asthmatic response, mast cells lead to generation of leukotrienes C4, D4, and E4 (early-phase reaction)

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