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free120/Block 2/Question#35 (0.9 difficulty score)
A 65-years-old woman with asthma is brought ...
B. leukotrienes πŸ”,πŸ“Ί

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submitted by moxomonkey(20),

In an asthmatic response, mast cells lead to generation of leukotrienes C4, D4, and E4 (early-phase reaction)

submitted by aakb(10),

I believe this is aspirin intolerant asthma. Aspirin inhibits cycloxygenase. This leads to more shunting of the arachidonic acid to the leukotriene pathway (excessively), which leads to a bronchospasm.

Aspirin-induced bronchospasms can occur in aspirin intolerant asthma occurs more in adults. Additionally, she experienced this previously with ibuprofen (another NSAID that inhibits cox).