acetaminophen toxicity will cause hepatic necrosis and thus bilirubin cannot get conjugated and stays in blood as indirect bili which makes the patient jaundiced.
acetaminophen is metabolized to NAPQI which decreases glutathione ---> liver cannot reduce toxic material --> hepatic necrosis.
submitted by โmeryen13(48)
acetaminophen toxicity will cause hepatic necrosis and thus bilirubin cannot get conjugated and stays in blood as indirect bili which makes the patient jaundiced. acetaminophen is metabolized to NAPQI which decreases glutathione ---> liver cannot reduce toxic material --> hepatic necrosis.