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Retired NBME 15 Answers

nbme15/Block 2/Question#29 (reveal difficulty score)
A 2-month-old male infant is brought to the ...
Glycine receptor ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: leishmania

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 +2  upvote downvote
submitted by โˆ—cheesetouch(250)
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Glycine is the only inhibitory neurotransmitter present. He likely has glycine encephalopathy is a rare autosomal recessive neurological disorder. Tetanus toxin - blocks release of inhibitory NT's gaba and glycine. Botulism - 'floppy baby ate honey' - inhibition of ACh release at the neuromuscular junction.

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 +0  upvote downvote
submitted by โˆ—medninja(21)
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This question sounded like botulism, anybody knows why is tetanus?

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bingcentipede  I think it's because of the last sentence - asks about a defect in an inhibitory neurotransmitter, with glycine being the only possibility. I think it's one of those "here's a stem, but just look at the last sentence" questions. +6
cassdawg  This actually is not tetanus or botulism. The deficit has been present since birth. He has glycine encephalopathy, a rare disorder (https://en.wikipedia.org/wiki/Glycine_encephalopathy). Definitely could be tricked into thinking botulism but defect in "inhibitory neurotransmitter" points to glycine deficit as glycine is the only inhibitory neurotransmitter listed! +4
cassdawg  (Disclaimer that I am assuming his deficit is just a weird kind of glycine encephalopathy because normally its a disease of metabolism not receptor; but it presents with the hiccups and seizures like seen in this baby. Big thing is the last sentence as was already said) +2

Here is more about glycine encephalopathy, which presents like the stem: https://ghr.nlm.nih.gov/condition/glycine-encephalopathy

+2/- cassdawg(1781)


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