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NBME 18 Answers

nbme18/Block 4/Question#36 (reveal difficulty score)
18 yo woman given general anesthesia for ...
Sarcoplasmic Ca2+ release ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–

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submitted by โˆ—cbrodo(77)

The patient has malignant hyperthermia, an adverse event associated with some anesthesia drugs (ie succinylcholine). The DOC for treating malignant hyperthermia is Dantrolene, which antagonizes the ryanodine receptor and results in decreased intracellular calcium.

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leemax  dantrolene-moa-sarcoplasmic Ca release +
fatboyslim  Note that succinylcholine can cause malignant hyperthermia but it is not an anesthetic, it's a neuromuscular blocking agent (paralytic) that may be used during anesthesia induction. Inhaled anesthetics (e.g. halothane) is what the question was referring to and they can also cause malignant hyperthermia. +

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