"Despite inhibition of HMG-CoA reductase by statins, cells compensate by increasing enzyme expression several fold. However, the total body cholesterol is reduced by 20%โ40% due to increased expression of LDL receptors after statin administration."
dhpainte22Another bullshit question that should've been straight to the point. Statins increase ldl receptors and inhibit hmg coA reductase. This should be simple but nbme can't live with that :(+5
jurrutiaI think they want to test not just your understanding of how statins work, but also the basic principle that when you block X the body tries to compensate by upregulating X. +9
submitted by โfamylife(110)
"Despite inhibition of HMG-CoA reductase by statins, cells compensate by increasing enzyme expression several fold. However, the total body cholesterol is reduced by 20%โ40% due to increased expression of LDL receptors after statin administration."
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hmg-coa