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NBME 18 Answers

nbme18/Block 1/Question#45 (reveal difficulty score)
55 yo man; father and brother died of ...
Increased transcription of HMG-CoA reductase ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm lipids

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 +20  upvote downvote
submitted by โˆ—famylife(110)

"Despite inhibition of HMG-CoA reductase by statins, cells compensate by increasing enzyme expression several fold. However, the total body cholesterol is reduced by 20%โ€“40% due to increased expression of LDL receptors after statin administration."

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md_caffeiner  fuck GoT, knowledge is power +1
dhpainte22  Another bullshit question that should've been straight to the point. Statins increase ldl receptors and inhibit hmg coA reductase. This should be simple but nbme can't live with that :( +5
jurrutia  I think they want to test not just your understanding of how statins work, but also the basic principle that when you block X the body tries to compensate by upregulating X. +9

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