dhpainte22
Another bullshit question that should've been straight to the point. Statins increase ldl receptors and inhibit hmg coA reductase. This should be simple but nbme can't live with that :(
+5
jurrutia
I think they want to test not just your understanding of how statins work, but also the basic principle that when you block X the body tries to compensate by upregulating X.
+9
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submitted by โfamylife(110)
"Despite inhibition of HMG-CoA reductase by statins, cells compensate by increasing enzyme expression several fold. However, the total body cholesterol is reduced by 20%โ40% due to increased expression of LDL receptors after statin administration."
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/hmg-coa