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NBME 18 Answers

nbme18/Block 2/Question#32 (reveal difficulty score)
Investigator studying vancomycin-resistant ...
Plasmid loss 🔍 / 📺 / 🌳

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submitted by mattfoley_govtcheese(7),
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submitted by match95(53),
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azibird  Why can't this be a point mutation? +6  
freenbme23  I don't think that this implies that it can't be point mutation, but rather plasmid loss is more likely. Also, the point mutation Would have to ultimately lead to the plasmid loss. +  
thrawn  FA says transposition is responsible for antibiotic resistance and plasmids are for transferring the genes of toxins (though UW says also antibiotic resistance). Make up your minds sheeple +  
mariame  The most common Vancomicin resistant genes, vanA and vanB are found in a transposon. These have been transferred from Enterococcus to a multidrug resistance plasmid in Staph aureus. the super multidrug resistance plasmid now contains resistance genes against lactams, vancomycin, aminoglycosides, trimethoprim, and some desinfectants. +2  
an1  @thrawn I recall that too, but I think it said transposition was antibiotic resistance and UW said transposons was for multi drug resistance +  

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