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NBME 18 Answers

nbme18/Block 2/Question#32 (reveal difficulty score)
Investigator studying vancomycin-resistant ...
Plasmid loss 🔍 / 📺 / 🌳
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 +27 
submitted by mattfoley_govtcheese(7),
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 +18 
submitted by match95(53),
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ortaissnToinp fo hte avnA egne fomr tneyitaacc-rnnvismos oecuscrotnEc is how ti trsafresn estaresnc.i Teyh ues aspsoonrstn hwcih era ldcotae no iml.sdaps fI you heav iadlspm sl,os yuo 'wton veha orsannsto,sp nda ercatsiens iwll eac.derse

azibird  Why can't this be a point mutation? +6  
freenbme23  I don't think that this implies that it can't be point mutation, but rather plasmid loss is more likely. Also, the point mutation Would have to ultimately lead to the plasmid loss. +  
thrawn  FA says transposition is responsible for antibiotic resistance and plasmids are for transferring the genes of toxins (though UW says also antibiotic resistance). Make up your minds sheeple +  
mariame  The most common Vancomicin resistant genes, vanA and vanB are found in a transposon. These have been transferred from Enterococcus to a multidrug resistance plasmid in Staph aureus. the super multidrug resistance plasmid now contains resistance genes against lactams, vancomycin, aminoglycosides, trimethoprim, and some desinfectants. +2  
an1  @thrawn I recall that too, but I think it said transposition was antibiotic resistance and UW said transposons was for multi drug resistance +  



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