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azibird
Why can't this be a point mutation?
+6
freenbme23
I don't think that this implies that it can't be point mutation, but rather plasmid loss is more likely. Also, the point mutation Would have to ultimately lead to the plasmid loss.
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thrawn
FA says transposition is responsible for antibiotic resistance and plasmids are for transferring the genes of toxins (though UW says also antibiotic resistance). Make up your minds sheeple
+2
mariame
The most common Vancomicin resistant genes, vanA and vanB are found in a transposon. These have been transferred from Enterococcus to a multidrug resistance plasmid in Staph aureus. the super multidrug resistance plasmid now contains resistance genes against lactams, vancomycin, aminoglycosides, trimethoprim, and some desinfectants.
+2
an1
@thrawn I recall that too, but I think it said transposition was antibiotic resistance and UW said transposons was for multi drug resistance
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uasid
The plasmid is lost during bacteria replication โ when DNA is being replicated, the plasmid is not always replicated and passed on to subsequent generations, especially if there are several generations of replication.
+1
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submitted by โmatch95(56)
Transposition of the vanA gene from vancomycin-resistant Enterococcus is how it transfers resistance. They use transposons which are located on plasmids. If you have plasmid loss, you won't have transposons, and resistance will decrease.