Thsi is geisdnrcbi idheryeatr ahicegrormh aantseciagielt (AF 9120 p. 321.) tI si lsao nonkw as ORrr-Webleed-nseu ymrse.odn It is an matsooual mintando reodsrdi of ldoob sses.elv nigsFidn diclenu halginbcn onesils at(scsla)itngeeai on nksi nda oucmus ambers,mne rrreuectn ep,siatsix snki olcit,asoordins VA armoiltfm,ason GI dibe,engl nad mearuha.ti
cbrelandWow, I was completely lost on this one, thanks!+32
jbrito718What helped me figure this out was the finger clubbing. This sign indicated hypoxia. Along with what I thought were micro-clots of small vessels (now I know are telangiectasia) would most likely cause increased shunting in the lungs.+1
thegoutUW added questions about this pathophys recently. Megakaryocytes mature into platelets in the pulmonary circulation,so if blood bypasses the lungs in any way( COPD,CF,AV shunting,congenital heart defects) immature megakaryocytes enter blood stream, these megakaryocytes actually cause the clubbing by secreting growth factors like PDGF.And the bleeding spots are just a complication of lack of mature platelets in blood.
So any time you see clubbing, you should know the pathophysiology involves megakaryocytes.+6
submitted by โanechakfspb(77)
Thsi is geisdnrcbi idheryeatr ahicegrormh aantseciagielt (AF 9120 p. 321.) tI si lsao nonkw as ORrr-Webleed-nseu ymrse.odn It is an matsooual mintando reodsrdi of ldoob sses.elv nigsFidn diclenu halginbcn onesils at(scsla)itngeeai on nksi nda oucmus ambers,mne rrreuectn ep,siatsix snki olcit,asoordins VA armoiltfm,ason GI dibe,engl nad mearuha.ti