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NBME 18 Answers

nbme18/Block 2/Question#45 (reveal difficulty score)
24 yo woman, remain in the intensive care ...
30 ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: pharm_calc

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submitted by โˆ—okokok1(38)

First order kinetics is constant fraction of the drug getting metabolized. So with the values given in the question stem, 16/32=.5 aka 50% of the drug gets metabolized every 6 hours. Then if you write out the decreasing doses (multiplying each value by .5) for until you get close to 1.1, it'll look like the following:

32->16->8->4->2->1

So it took 5 half lives to get to 1 (closest to 1.1). So since each half life is occurring at every 6 hours, you then multiple 5x6=30.

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