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Retired NBME 19 Answers

nbme19/Block 4/Question#47 (reveal difficulty score)
In the diagram of the proximal renal tubular ...
C (no carriers, going from lumen to basolateral side) ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—hungrybox(1277)
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I got confused with aquaporins so I picked E :(

But aquaporins are in the collecting duct, NOT the proximal tubule

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j44n  there are AQP's in the PCT but they're not that abundant. Look at it this way, AQP's are by definition a transporter and therefore they can be saturated. The PCT is the king of all resorption and a big reason for that is paracellular transport, which can't be saturated. This also makes sense as to why we can treat nephrogenic DI witha thiazide, it causes INCREASED resorb at the PCT which can over power the rest of the nephron. The PCT does everything and the rest of the nephron gets the left overs +3



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submitted by โˆ—hungrybox(1277)
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