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Retired NBME 19 Answers

nbme19/Block 2/Question#40 (reveal difficulty score)
Which of the following best explains the ...
Stimulation of release of prolactin from the adenohypophysis ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—surgerydoctorca_sgu(6)
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(FA 2021, Pg. 338)

This question is testing your knowledge of dopamine antagonist (e.g. antipsychotics, metoclopramide). Dopamine antagonists and estrogens (e.g. OCPs, pregnancy) stimulate prolactin secretion).

What really important this though is to know and I think a lot of people get confused is that when prolactin production is blocked off via the dopamine pathway, the hypothalamus re-routes through thyroid releasing hormone (TRH) and then back through the anterior pituitary to stimulate prolactin secretion which then causes the galactorrhea in the patient.

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