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Retired NBME 19 Answers

nbme19/Block 2/Question#48 (reveal difficulty score)
A 67-year-old man comes to the physician for ...
Ubiquitin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—surgerydoctorca_sgu(6)
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This question is testing you knowledge on skeletal muscle adaptations (specifically atrophy). The patient is described to have cachexia and significant muscle wasting, these are manifestations of atrophy. Atrophy occurs via:

  • Decreased myofibrils (removal via ubiquitin-proteosome system)
  • Decreased myonuclei (selective apoptosis)

It is important to know the molecular mechanisms of atrophy above as these are what the test makers love to test your cellular and molecular knowledge on many concepts.

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