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NBME 19 Answers

nbme19/Block 3/Question#41 (reveal difficulty score)
Immunization of a 3-month-old infant with ...
CD40 - CD40 ligand 🔍 / 📺 / 🌳 / 📖

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submitted by surgerydoctorca_sgu(6)

This question is testing your knowledge on T- and B-cell activation.

My specifically it is asking about B-cell activation and class switching. The following steps occur during this process, and step 4 is what you need to know in order to answer this question correctly:

1) Th-cell activation as above. 2) B-cell receptor–mediated endocytosis. 3) Exogenous antigen is presented on MHC II and recognized by TCR on Th cell. 4) CD40 receptor on B cell binds CD40 ligand (CD40L) on Th cell. 5) Th cells secrete cytokines that determine Ig class switching of B cells. 6) B cells are activated and produce IgM. They undergo class switching and affinity maturation.

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