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Retired NBME 19 Answers

nbme19/Block 3/Question#28 (reveal difficulty score)
40 yo man, 1 month increasing malaise, ...
Hepatocytes ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +7  upvote downvote
submitted by โˆ—cassdawg(1781)
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This individual has active Hepatitis B, as evidenced by their Hepatitis B surface antigen positivity. Hepatitis B virus productively infects hepatocytes. The CD8 cells will thus attack the hepatocytes.

Another way of approaching this question is to notice AST and ALT elevation are typically indicative of hepatocyte damage.

Ito cells are the same thing as stellate cells, and their primary function is to store vitamin D and fat and produce ECM when activated. Kupffer cells are the liver's macrophages. Bile duct epithelium is not infected in hepatitis.

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moms  Exactly. But Ito cells (located in space of Disse) store Vitamin A when they are quiescent and produce ECM when they are activated. Basically are responsible for hepatic fibrosis. p. 367 FA 2020. +7



 +0  upvote downvote
submitted by โˆ—unknown001(9)
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this was one of the easiest questions, and its a shame i missed it.

recall : ground glass appearance which is classic. for hep B are simply antigens in the hepatocytes.

so cd8 will target those

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