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NBME 19 Answers

nbme19/Block 3/Question#49 (12.3 difficulty score)
Schematic representation of eukaryotic translation
Binding of aminoacyl-tRNA to the A siteπŸ”,πŸ“Ί
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 +3 
submitted by wherearetheanswers(11),

Another tRNA has to attach to the A site before the peptide chain can be hydrolyzed from the P site and moved to the A site tRNA (FA 2020 pg 45)

fataldose  As the Peptide chain is transfered to the tRNA at the A site, the ribosome moves down the mRNA moving the now empty P site tRNA to the E site, and the tRNA from the A site to the P site, making room for the next amino acid charged tRNA to attach to the A site. Additional points- The translation comes to an end when a releasing factor recognizes one of the stop codons (does not code for an amino acid), which then catalyzes the release of the peptide chain from the tRNA in the P site. Peptidyl transfer to E site is wrong because peptidyl tranfer occurs between P site to the A site, not to the E site eIF4E is a eukaryotic translation initiation factor involved in directing ribosomes to the cap structure of mRNAs. Once methionine charged tRNA locates the start codon, all initiation factors are released. +6