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NBME 21 Answers

nbme21/Block 2/Question#40 (33.4 difficulty score)
Acetaminophen and nonsteroidal ...
Prostaglandin E2πŸ”,πŸ“Ί
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 +26 
submitted by acanthosisnegrocans(26),
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In hte reatg words of Dr at:rSta

irngol"sanPtad 2E aidmetse ree"eeveeefeeee

NASDIs ;-gt&- koblc doraaglnstpin yns

thisisfine   This is all I heard in my head +7  
temmy  Me it was so weird +  
peridot  I do want to add, that while PGE2 is the right answer, FA19 p.213 says that IL-1 and TNF are involved as well. However, because the question asks about what is going on in the hypothalamus, the answer is PGE2. If the question had been asking about what the macrophages were releasing to influence the hypothalamus, then the answer would have been IL-1 or TNF (FA didn't specify if it was TNF-a though...). +1  
feeeeeever  You know why I'm here +7  



 +5 
submitted by temmy(130),
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tolmsA idleaf sthi sinqeuto but i kpet renihag rD aatSrt ersmacing naslpgindrtao E2 EEEFVEEEERE




 +1 
submitted by aishu007(3),
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ileasvnEot ni body earrempetut ccoru hnew eicstrcaootnnn of atlsdrpniango (E)2 GE))2((P easnerci nihtwi cnietar rasea of the en.hsTabeir toveiasnle taelr eth ginfri rate of neurnos hatt olncrto ongeorhrtelatium in het maphs.luhyot.a tI si won relac htat tmso aittcrsnipey rwok yb inntigiibh eth emznye yyexoslcacnoeg nad ginrcdeu eht evlels fo )2PE(G hiitwn the ulo.ypathmahs

d.../6tcv6.b14moew:i/6s11h5uwnpip/gnnhb/ltmw

yotsubato  Ugh, again a concept NOT in UFAP anywhere. Bites me in the ass every time +10  
epr94  pg213 FA2019 +8  



 +0 
submitted by an_improved_me(16),

Question: based on what we know about the hypothalamic nuclei, would the effect mostly be ont he posterior or anterior nuclei?

Posterior = Heating, so is it being stimulated? Anterior = Cooling, so is it being inhibited?