NBME 21

nbme21/Block 3/Question#34

A 39-year-old woman with rheumatoid arthritis ...

Membranous glomerulonephritis

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submitted by mcl(0),

Membranous glomerulopephritis (aka membranous nephropathy, p 584 FA 2019) may occur secondary to drugs such as penicillamine. Immunofluorescence shows granular deposits due to immune complex deposition. Will also see diffuse capillary and GBM thickening, and SEM will show spike and dome appearance due to subepithelial deposits.