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Retired NBME Free 120 Answers
focus
Ugh I was thrown off by "disruption of vascular basement membranes" since it seemed similar to the correct answer but I can see how "separation" would be a normal, expected response of the body that is needed vs. "disruption" would be traumatic and abnormal... please correct me if I am wrong!
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blah
@focus reasoning sounds right. I nearly picked that but the other choice sounded better. Just semantics.
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aakb
um just to clarify I don't think the differentiating factor is the wording of separation vs disruption.
but rather that the correct answer is separation of ENDOTHELIAL junctions meaning that the spaces between the endothelial cells get wider.
vs the answer youre thinking of says the disruption of the vascular BASEMENT MEMBRANE (which is under the endothelial cells) gets disrupted. so meaning something literally broken through the blood vessel and made a cut in the layer beneath the endothelial cells that line the blood vessel
Dr. Sattar from pathoma usually draws a basement membrane and a layer of endothelial cells sitting on top
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fhegedus
Eosinophils (FA 2020 page 408) are involved in type I hypersensitivity reactions (asthma, allergy, analphylaxis), parasitic infections and other pathologies. They are not involved in edema formation. I hope this helps! :)
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fhegedus
Also, the patient in the question got a laceration, which probably led to a bacterial infection; so neutrophils would be predominant, not eosinophils.
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submitted by โbwdc(697)
Endothelial tight junctionsโ permeability is increased in response to injury and inflammation, allowing migration of white blood cells and friends to the site of injury.