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free120/Block 2/Question#40 (reveal difficulty score)
A 62-year-old man comes to the physician for ...
Type I pneumocytes: decreased;
Type II pneumocytes: increased;
Fibroblasts: increased
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 +7 
submitted by benwhite_dotcom(622),
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heT p’aitsnet rihocnc aynoarfiltmm uniponmties is lngliik off ihs gunl anaryhecpm (spdmeoco lpamiyrri fo teyp I pmcn.oyteues) yepT II pt,nyoeceusm in tiniadod ot imnakg satacurtf,n can pecieltar ni deror ot pcelear ytpe I ptmy,snceueo so thye lwil eb ncedear.is niCcroh tnattlriisie mtfnaoinamli usstrle in ,bfrisios ehecn an eneasicr ni sloitfs.abbr

len49  UW ID 666 has a great explanation. +4  
melchior  From the UW ID 666 explanation, although type II pneumocytes normally differentiate into type I pneumocytes after proliferation, they do not differentiate in idiopathic pulmonary fibrosis due to altered cell signals and altered basement membrane, which is why type II pneumocytes are increased. +7  



 -3 
submitted by b1ackcoffee(71),
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rofm lmoreci@h

Form hte WU ID 666 aptox,leanni hualghto ptey II ncmoeyuptse rmyloaln rnffeteeaiidt tnio yetp I uoysemtcenp freat ,ooltrfpnierai yhte od not iteerietdfnfa in iaocihtdpi umanpoylr birofsis ude to aerdlte cell nlgassi nda daetrel eeabsnmt ne,mbrmea hwchi is yhw eypt II eeocyuntspm are dnraceies.

axtinnoepla yb @mneboit_cwodeht is rrtcnoiec

peridot  The UWorld example is talking about idiopathic pulmonary fibrosis, whereas benwhite_dotcom was talking about chronic inflammatory pneumonitis, which presents with increased type II pneumocytes (as indicated by the correct answer). +2  
topgunber  either way destruction of basement membrane leads to type II hyperplasia. It may leads to fibrosis because of destruction of the basement membrane (the point of no return for lung parenchyma). Type I pneumoyctes will not rise in number because the destruction in the basement membrane (they are the vast majority of cells covering alveoli) +3  



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