NBME Free 120 Fatty acid oxidation (NBME Answers)

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Retired NBME Free 120 Answers

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Six healthy subjects participate in a study ...
Fatty acid oxidation 🔍 / 📺 / 🌳 / 📖
tags: biochem metabolism

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submitted by ∗bwdc(697)

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Malonyl-CoA inhibits the rate-limiting step in the beta-oxidation of fatty acid. Logically, resting muscle requires less energy (and thus less need for fatty acid breakdown) than active muscle.

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zpatel it inhibits Carnitine acyltransferase-1 in beta-oxidation. +6

melchior FA 2020 pg 89 +1

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submitted by ∗b1ackcoffee(115)

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If you are making fatty acid, you should not burn it simultaneously.

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submitted by ∗beltorres23(10)

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Uworld Qid 11918 has a perfect explanation for this

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drdoom can you summarize? thanks! +1

beltorres23 Beta oxidation of fatty acids occurs within the mitochondrial matrix. The mitochondrial membranes are impermeable to fatty acids and rely on carnitine to shuttle them into the matrix. Elevated levels of malonyl coa inhibits carnitine acyltransferase, preventing fatty acid transport into the mitochondria and thereby inhibiting fatty acid oxidation. +5

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submitted by ∗handsome(3)

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FA 2020 PG 73 There's a table where you can see Malonyl-CoA - as regulator; Carnitine acyltransferase I as enzyme and Fatty acid oxidation as process.

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submitted by ∗handsome(3)

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FA 2020 PG 73 There's a table where you can see Malonyl-CoA - as regulator; Carnitine acyltransferase I as enzyme and Fatty acid oxidation as process.

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