NBME Tumor necrosis factor α (NBME Answers)

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free120/Block 3/Question#15 (15.7 difficulty score)
A 46-year-old woman with active ankylosing ...
Tumor necrosis factor α🔍
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+6
submitted by em_goldman(22),

Rituximab (anti-CD 20) is currently undergoing trials for AS. My sparse googling just now shows that rituximab probably only has a moderate effect, so probably second-line to anti-TNFa therapy. Probably.

Safe to say for boards that AS: TNFa > CD20

cheesetouch FA 2018 - rituximab p 430 -- - use for Nonhodgkins lymphoma, CLL, ITP, Rheumatoid arthritis TNF-a inhibitors - p 472: 1) etanercept for Ra, psoriasis, ankylosing spondylitis. 2) infliximab and other mAB for IBD, RA, AS, psoriasis +1

+2
submitted by osler_weber_rendu(86),

Monoclonal Antibodies are always last resort! I just use this as a general rule

+1
submitted by benwhite_dotcom(465),

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