NBME Free 120 Binding to the 30S ribosomal protein (NBME Answers)

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Retired NBME Free 120 Answers

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A 67-year-old woman with congenital bicuspid ...
Binding to the 30S ribosomal protein 🔍 / 📺 / 🌳 / 📖
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submitted by ∗69_nbme_420(36)

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Aminoglycosides (Which inhibits 30S) are coupled with cell wall active agents - e.g. Penicillins, Vancomycin

(Sketchy Reference on Aminoglycoside Sketch: Beta-lactam bomb!!)

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submitted by ∗studentdoc1996(1)

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Aminoglycosides are synergistic with beta lactam antibiotics (and penecillin is a type of beta lactam antibiotics). The question is saying "what will make this work faster?" basically

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submitted by ∗melchior(79)

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Couldn't find this in FA or SketchyMicro, but it seems that

"the role of aminoglycosides in the treatment of infective endocarditis is well established. The combination of a beta-lactam with an aminoglycoside shortens the treatment of endocarditis due to... streptococci" 1996 https://www.ncbi.nlm.nih.gov/pubmed/8677414

and "Aminoglycosides are often used in combination with glycopeptides (such as vancomycin) and β-lactams for the treatment of bacterial endocarditis caused by α-haemolytic streptococci, staphylococci and enterococci." 2002 https://academic.oup.com/jac/article/49/3/437/727559

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submitted by xw1984(8)

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Per FA, should aminoglycosides be used in gram negative infection? S.viridans are Gram positive.

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