Is the decrease in baroreceptor output due to the body adapting to the hypertension?
azibirdApparently. "Baroreceptor activity is reset during sustained increases in blood pressure so that in patients with essential hypertension, baroreceptor responsiveness is maintained."
"It is a universally accepted phenomenon that vascular baroreceptors reset to operate at higher pressure levels in hypertension."
Okay, so they can reset to normal levels, but wouldn't this patient already have undergone their reset? Why would the receptors further decrease?
I thought that eventually their LV would hypertrophy and fail, leading to decreased stroke work.
azibirdFrom Costanzo Physiology:
"The sensitivity of the baroreceptors can be altered by disease. For example, in chronic hypertension (elevated blood pressure), the baroreceptors do not “see” the elevated blood pressure as abnormal. In such cases, the hypertension will be maintained, rather than corrected, by the baroreceptor reflex. The mechanism of this defect is either decreased sensitivity of the baroreceptors to increases in arterial pressure or an increase in the blood pressure set point of the brain stem centers."+132020-05-14T21:33:01Z