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NBME 16 Answers

nbme16/Block 3/Question#3 (reveal difficulty score)
A 49-year-old woman with breast cancer ...
Microtubules for axonal transport ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–

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submitted by โˆ—cassdawg(1778)

"Vincristine crisps the nerves" (FA2020 p441)

Vincristine is a common cause of chemotherapy-associated peripheral neuropathy (with cisplatin also having an association with neuropathy but not being used for breast cancer). Vincristine acts by binding tubulin and inhibiting microtubule polymerization. This affects cancer cells by inhibiting division, but also affects axons by inhibiting axonal transport.

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feochromocytoma  SO does it's brother, Vinblastine, it blasts the nerves! +
letitb  Vinblastine BLASTS the BM, not nerves. its associated with BM suppression. +1

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