ACUTE alcohol inhibits CYP → Increased bioavailability of acetominophen
CHRONIC alcohol induces CYP → Induction of cytochrome P450 enzymes that activate acetaminophen to a hepatotoxic metabolite
I got this wrong because I assumed chronic alcohol meant years and years. I guess a weekend will suffice?
Honestly, fuck this problem.
Acetaminophen is mainly glucuronidated and minimally metabolized to NAPQI by CYP 450 enzymes
Chronic alcohol consumption induces CYP 450, so more acetaminophen is metabolized to NAPQI