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NBME 16 Answers

nbme16/Block 3/Question#1

A 20-year-old man is brought to the physician ...

Induction of cytochrome P450 enzymes that activate acetaminophen to a hepatotoxic metabolite

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submitted by feliperamirez(1),

Acetaminophen is mainly glucuronidated and minimally metabolized to NAPQI by CYP 450 enzymes

Chronic alcohol consumption induces CYP 450, so more acetaminophen is metabolized to NAPQI

detayo  Would this qualify as chronic alcohol though? +  
detayo  Would this qualify as chronic alcohol though? +