This man presents with classic features of Parkinson Disease which is caused by degeneration of dopamine producing neurons in the substantia nigra (FA2020 p520)
ibpstepprepmost likely Chronic traumatic encephalopathy (CTE), Parkinson like symptoms and history of boxing/ traumatic sport. Repetitive trauma results in neuronal degeneration and Tau deposition. +11
shieldmaidenThe problem with a diagnosis of CTE here is that it shares more sxs and etiological features with Alzheimer's, making it a cognitive-heavy disease rather than movement, like what is seen in this patient. The repeated trauma might have played a part but in this case, where a person is having trouble with movements, not memory, behavior, personality, or mood, I think is more accurate to say that it's Parkinson's and thus neuronal degeneration and not a tauopathy. +2
shieldmaiden@msula I think ALS is not associated with sleep disturbances, pain, or tremors. Furthermore, the question points you to a defect in the patient's brain, so that also r/o ALS+
submitted by โcassdawg(1781)
This man presents with classic features of Parkinson Disease which is caused by degeneration of dopamine producing neurons in the substantia nigra (FA2020 p520)