itvneiyitHsrypises ypTe I: ALET SNPERSOE.

Imietmeda m)(etsu:ni ngneiat klsdrosirpefrm oecsn EgI on idespniseetzr stma eclls

iedeatmmi gaonrdnauielt gt&; seralee oeihts fainm a( iavovetacs ni)eam nad aeatpt ry(s erakmr of amst clel ntiatco.)iva

taeL o(uhsr): noieecshkm ofmli( tnattrayaratcm lls,ec ,eg pilh)esooins raonh dte seotmrdai (e,g )ulonretekies form amlsc tels > latmimnoinfa and teusis gm.adae

AF 0202 P 112

hTis (tlae bee sngit rxn) is enibsridgc an hrAsut ctieanor le(dzoacli Teyp III )RHS + gIG umemin seeopcxlm cmcautleau ta siet ;t-&g- stam cell teuigaonnradl t-&g;- Niourptelh t c+mretrueni IGg numeim slpemoxec oals eltisamut apcmrghoesa to eseealr irmolmantyfa ikoncyest -LI(1, LI-,6 aNT-F) adn icshkenmeo I(L-)8 g;t&-- ueNoltrhip meircetrtnu s eltru in suomtedae nartdduie lsinoe

ineeTilm ofr rtsahu aoncerit e eb n:stgi -18 rush,o nley:egarl 2-16 sruoh sv eLat pheas peyT 1 SRH 2-4 horsu

w--scsihtce-.prcctsw/scnaiomion/rtm:m/iiab/og/guhd.oloituemooorptwyyndlctcaereni

ihsT NBEM ntieqosu si aodedt;tu edsBa on a ialsirm otisunqe ni RDULW sehte ninfsidg of ucaaiirrt ofwelodl yb uaniotdnri ni a wfe ourhs era esniotnstc whit hte arlye dna tela sspeah fo a ytpe I itneytyvihressip .ecartnio

Ftsri pusrxoee to an anegerll nigtena e&ipi;-sftcgc EIg is eprcuddo by B-llsce nda bnsid to teh faeurcs fo atms lces.l

Eyarl ae:psh erepat uoxseerp bnodu IgE -ksioslcrn adn ttasliuem reaslee of drmpoeerf etinahism dna enelsuorietk atht sucea idoalavtnsoi adn aeecrsnid rayllacip be.liyeraiptm heT ersulst uaiiecprsfl laemrd aemed nad eahmyrte ehalw( dan lfrea eaict)orn htta can oesgprsr ot a ermo imectsys rsnpseoe l)naxh.s(aiyap

Ltae eap:hs EgI uetlmaisst etpy 2 lrephe T lcels ot aeslree netsykioc ()I-L5 taht teiatcav lssopioen.hi ictnCoai ritpoens oja(mr csabi rotp,ine pionshielo ri)sdxpoeea rldeeeas mrof phonosliesi ucaes usseti emad,ga hihcw alyuslu fnisamets sa a le,lpapba rdtdnaieu nileso 102- rosuh nloogliwf eht lheysepar-a .ctnioear

Tshi is finrtefde rfmo hte atndinriou ew see ni yldaeed eypt( IV) ienthyvysiietpsr eatircnso wereh D4C T lescl eseealr kiseytonc eetf(irornn )amamg ttha otomepr T clel- dna eetamoahidger-capdm ueisst agadem subacee ytpe IV srvyisepnhtytiie nastrioec evoldpe evro dyas teahrr( tnah horsu) ude ot eth eimt eeendd ofr llucrlea lnpmitiicfaa.o

(FA 0202 Pg 1)24

uceAt ninaatfmiolm + oniolidatVas fo esatuuarlcv adn easdnriec eiltdehoanl liybp.mietear LI,1 IL,6 dna TaNF rae lal edoinvlv in uctea .olmntnifimaa