intyteyripsvesHiis ypTe :I LETA .PNSROEES

aeIdemmti )mnitesu(: ngenait rifoesdler spsmnocrk IEg no siesdrintzpee amts slcle

dtimaemie atdngnruealoi g&t; esereal fa ntosimhie a( vtsviaocea anm)ei adn ps( atteray ermark of samt cell taoc).aniitv

Leta s(r)ou:h nhicksoeme r(tcmitflanaarmyt aot secl,l g,e phose)onisli hrtdonea retmdoisa (eg, irnlueketoe)s omrf esslla tcm &tg; flimoinaantm adn usesti geda.am

AF 2200 P 121

ishT ate(l eeb nsigt nxr) si rigdnbcesi an Arhtus aitorcne lacozild(e eyTp III S)HR + IgG unimme oelsepxmc acatmuluec ta iest gt-&;- atms clel ouganlrinetad t&--;g iopelNrtuh etcruet+imnr IgG imnmeu xpcleosem losa tmsulaiet paoahcgerms to eaelrse rlimfmyntoaa incytoesk ,I(1-L IL-6, a)F-TN and hnemoiecks )L(I-8 &tg;-- lpeNutoirh menitteucrr lsture in usamedteo ndeatidur nleosi

lnTmeeii orf htsaur aroctnie ebe sngti: 8-1 husr,o nry:glleea -162 uhrso vs tLae epahs yepT 1 HRS 24- hsoru

.eoo/smric-tyshoic:gc/naycrugueteatocihmeanoidmspctrwtb.icpl/wd-rn/osio/linowm-t

Tish EBNM oitnsuqe si d;eottdau eBdas on a lamiris uineqsto in RDLUW sehte idnfsing of uraatiicr dfloowel yb nondriutai in a ewf rsuoh ear sconetisnt wthi eht eylar adn atle hspesa of a ytep I viniyssihtryteep crt.oeina

sFirt eexrspou to na neaerlgl gieannt ciepstg;ic-f& IEg si ddrpcuoe by cselBl- nda sinbd to teh acefusr fo amts ellc.s

rlyaE s:haep tepear eposxuer duobn EgI lkrnisocs- adn tuteamsli esrelea of dmofreper ntiesimah and sikeetoulner ttah eusca saovinltoida nad aescidrne alcpalyir pb.eiyilametr Teh ssrulet csrepafiliu rdmale emaed and ehmaryte e(lhwa nad falre aoetnrc)i thta can gospsrre to a emro itmsysec srsenpoe lhyn.i(pas)xaa

eaLt ehs:ap gEI usmsltaite ypte 2 lheerp T slecl ot seleaer csntkeyio )-5I(L taht tcitaaev ehosi.olipns nactCoii snpoiert omajr( sbcia t,ierpno soenlhiiop dsorepax)ie ldrseeea rfom npoioslishe uaesc euists edagm,a wcihh slluauy nsafeimst as a lapp,ebla ruaniddte seinlo 021- ursoh olofwlgin teh plsarah-yee ion.rcate

ihTs is freetnfid mfro teh dnuaiotirn we see in dedalye pe(yt V)I eiessyirvpiytthn cetiarson erewh 4DC T ecsll ealeser nkcsoiety rieronntfe( m)agam ttha ooetrpm T ecl-l nda eodearcmgaamh-ipedt estius agadem beseuca tepy IV vyriipithtnseyse irtanoesc oepledv rove ydas arthr(e hnta hr)ous deu to het time dneede fro allelruc cianlpiafoti.m

AF( 0220 Pg )421

tucAe tiofmaanlnmi + oasintViadlo of vuterulacsa adn crsdeeina nlidahleote iimpea.tlrbye I1,L IL6, dan FNaT era all ivoenlvd in ecuat aotmafniil.nm