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Retired NBME 16 Answers

nbme16/Block 4/Question#34 (reveal difficulty score)
An investigator is conducting a study of ...
P. vivax and P. ovale ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1781)
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Plasmodium vivax/ovale have a dormant hypnozoite form which infects the liver and can remain dormant. This is why P. vivax/ovale must be treated with primaquine on top of chloroquine (because only primaquine can kill the hypnozoites in the liver) [FA2020 p157]

An additional important fact, Plasmodium vivax/ovale have the "tertian" (48-hour) fever cycle on the first and third day.

NOTE: You would also NOT want to use chloroquine to treat P. falciparum because resistance is too high among that species. However, this is not the reasoning given in the question.

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