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Retired NBME 16 Answers

nbme16/Block 1/Question#46 (reveal difficulty score)
A 28-year-old woman comes to the physician ...
Wegener granulomatosis ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—cassdawg(1781)
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This is Wegener's granulomatosis (granulomatosis with polyangiitis) for the following reasons: (FA2020 p314)

  • Recurrent sinusitis, perforation of nasal septa, pulmonary nodules - symptoms of Wegener's
  • PR3-ANCA = antibodies against proteinase 3, this is the primary clue and requires that you know that anti-PR3 is the same thing as c-ANCA which is characteristic of Wegener's
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