Phenoxybenzamine is an irreversible non-competitive antagonist on alpha receptors that prevents catecholamine (hypertensive) crisis. It is used preoperatively for pheochromocytomas.
FA18 p 334. Tx for pheochromocytoma is irreversible alpha antagonist (phenoxybenzamine, a1a2 blocker) followed by beta-blockers prior to tumor removal. Need to get alpha block BEFORE giving beta blockers to avoid hypertensive crisis.
submitted by โmotherhen(69)
Phenoxybenzamine is an irreversible non-competitive antagonist on alpha receptors that prevents catecholamine (hypertensive) crisis. It is used preoperatively for pheochromocytomas.