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NBME 16 Answers

nbme16/Block 1/Question#36 (6.0 difficulty score)
A 10-year-old girl is brought to the ...
Leukotriene C4πŸ”,πŸ“Ί
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 +2 
submitted by fruitkebabs(23),

The only reason I got this was remembering that Montelukast and Zafirlukast, both asthma drugs, inhibit LTC4, LTD4 and LTE4 which normally acts to increase bronchial smooth muscle tone.

FA 2020, p485




 +1 
submitted by topgunber(42),

another way to remember this is NERD. NSAIDs-exacerbated respiratory disease (NERD), when blocking COX there is shunting of the Arachadonic acid breakdown into the LOX (lipooxegenase pathway) which can cause build up of leukotrienes and cause an asthma-like condition.